A3281

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A3281

Sigma

 

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride

Synonym:W-7
CAS Number:61714-27-0
Linear Formula:C16H21ClN2O2S · HCl
Molecular Weight:377.33
Beilstein Registry Number:6030174
MDL number:MFCD00012559
PubChem Substance ID:24278067

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Description

Biochem/physiol ActionsA calmodulin antagonist; inhibits Ca2+/calmodulin activated phosphodiesterase and myosin light chain kinase.

Properties

Gene Informationhuman ... CAMK2A(815), CAMK2B(816)
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements22-24/25
WGK Germany3

References

referenceSuzuki, Y.J., et al., Modulation of Ca2+ channel-gated Ca2+ release by W-7 in cardiac myocytes. Cell Calcium 25, 191-198, (1999) Abstract
 Osawa, M., et al., Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding. FEBS Lett. 442, 173-177, (1999) Abstract